Research Associate in Preclinical Musculoskeletal Imaging and Biomechanics

Job Description

This highly interdisciplinary Research Associate position will advance our understanding of the effect of biomechanical and pharmacological treatments for Osteoporosis (OP) in a mouse model. The position is within Insigneo and is funded as part of a project selected by the ERC-Consolidator and funded by the EPSRC that aims to develop and validate new multiscale computational models for optimising treatments for OP. This part of the project is focused on the collection of experimental and imaging data to inform and validate the models.

The ideal candidate will have an excellent PhD in musculoskeletal imaging, biomechanics or a related discipline. They will possess a solid knowledge of bone and muscle imaging and experience with in vivo mouse experiments. Ensuring the achievement of the project objectives will advance the vision of the Insigneo institute to validate computational models for the musculoskeletal system and produce a transformational impact on healthcare. The Research Associate will also sustain and strengthen collaboration within relevant Insigneo research groups and beyond; and will commit to Insigneo’s mission to produce high quality and impactful cutting-edge research.

The successful candidate will develop microCT and microMRI in vivo imaging approaches to measure longitudinally the properties of bones and muscles in mice. They will also establish a mouse gait laboratory for the 3D longitudinal assessment of movement in mice. These approaches will be used to measure the effect of Osteoporosis and related treatment on the musculoskeletal health and mobility and to inform and validate computational models of bone adaptation developed within the team.

The Research Associate will work collaboratively with other colleagues within the IMSB group, the SkeletAl laboratory, and the Insigneo institute to validate the first inter-species (mouse and human) virtual twin for optimising treatments for Osteoporosis.

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